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KMID : 0370219820260030181
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Yakhak Hoeji
1982 Volume.26 No. 3 p.181 ~ p.184
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Synthesis of Iron and Copper Complexes of 2-Formylpyridine Thiosemicarbazone Derivatives, Potential Antitumor Agents
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Kim Jong-Yoon
Choi Bo-Gil
Woo Soon-Hyung
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Abstract
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The iron and copper chelates of 4-dimethylamino-2-formylpyridine thiosemicarbazone, one of the amine substituted derivatives at 4-C of 2-formylpyridine thiosemicarbazones which are known as the more improved potential antitumor agents, have been synthesized to make them more effective than the ligand (denoted as HL) itself. Their ligand-to-metal ratios were 2:1 and 1:1 for the iron and copper chelates, and the data along with those of elemental analysis and IR spectroscopy showed that. the compositions are [ and [CuL(O)], respectively.
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